the 3 major hypotheses of psychosis and their nerotransmitter networksdopamine theoryglutamate theory serotonin theoryFigure 1 The dopamine hypothesis of psychosis. For half a century, psychosis, particularly auditory hallucinations and paranoid delusions, have been thought to be the result of hyperactivation of the dopaminergic mesolimbic pathway. The mesolimbic pathway projects from the ventra..